Almond Button Mushroom
Agaricus blezei





 

Please write on A. blazeid

90 vegetarian capsules / 400 mg per capsule
$29.95 per bottle

Suggested Use
2-6 capsules daily

Product Information
Agaricus blazei is a relatively new addition to the family of medicinal mushrooms with research beginning in the 1980's. This species contains a unique beta 1-6 linkage and has an extensive history of use as a folk remedy in the areas of Brazil where it was originally discovered. Research has also shown that Agaricus blazei contains more beta glucans than any of the other medicinal mushrooms tested so far. The in-vitro research and animal studies both show significant immune stimulating properties.

Research has been done on water soluble and alcohol soluble fractions of the polysaccharides, all of which were isolated through a hot water or hot water/alcohol extraction process. As with the other medicinal mushrooms, the primary active compounds in Agaricus blazei, the polysaccharides, are internal structural components of the indigestible cell walls. Extraction with a heated aqueous solution is required to release these active compounds into a bio-available form.

Our product is a hot water/alcohol extract, ensuring the presence of both the water and alcohol soluble fractions of the polysaccharides. Our 45% polysaccharide extract is the most potent extract available and is the only hot water extracted form of Agaricus blazei now being sold in North America.

 

 

 

Agaricus blazei Muril

Agaricus blazei murill mushrooms are unique organisms, stationary like a plant, yet built from chitin (ki -tin) like the shell of a lobster. Understanding the properties of chitin is the key to understanding how to choose an effective, high quality medicinal mushroom product.

Chitin is indigestible by humans, yet the chitin, which makes up the cell walls of mushrooms, contains the potent immune building compounds common to all medicinal mushrooms, the polysaccharides. Indisputably, only heat can break down the indigestible chitin and release the active compounds into a concentrated, bio-available form. Therefore Agaricus blazei Murill mushrooms are always prepared with heat and water, as a tea or a decoction and never used in the un-extracted form (as dried mushroom powder or dried mycelium powder), and never prepared as a tincture (soaked in alcohol alone in the absence of heat).

Scientists have also recognized the importance of heat. It is no coincidence that every significant scientific study on the use of Agaricus blazei Murill mushrooms for immune health has been conducted with a heat-based extract, thats what Asians researchers developed in long years studies.Therefore we offer dehydrates hot water extracts where the heat releases the polysaccharides from the chitinous cell walls of the mushroom and mushroom mycelium.

1000 ml of extract includes 2,2 lbs of Agaricus blazei Murill. If you would now prepare dried Agaricus blazei Murill in form of tea. you would drink at least 35 liters of water for the same amount of used dried mushrooms. This means you get a easy to take strong Agaricus blazei Murill product from Brazil. To preservate and sterilizate are used the most natural technologies.

This means for that people who don't have the possibilities to prepare every day fresh the Agaricus blazei Murill tea or don't want to take so much liquid, the Liquid Hot Water Extract is the most natural strong alternative.

Research with Agaricus blazei Muril
J Nutr 2001 May;131(5):1409-13

Isolation of an antitumor compound
from Agaricus blazei Murill
and its mechanism of action.

Takaku T, Kimura Y, Okuda H.
Second Department of Medical Biochemistry and Central Research Laboratory,
School of Medicine, Ehime University,
Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.


The Basidiomycete fungus Agaricus blazei Murill has traditionally been used as a health food for the prevention of cancer, diabetes, hyperlipidemia, arteriosclerosis and chronic hepatitis.

In the present study, we examined the antitumor activities of various substances isolated from the lipid fraction of A. blazei. Tumor growth was retarded by the oral administration of the lipid fraction extracted from A. blazei with a chloroform/methanol mixture in sarcoma 180-bearing mice.

The substance with the antitumor activity in the lipid fraction was isolated via silica gel column chromatography, eluted with an acetonitrile/methanol (3:2) mixture and identified as ergosterol by direct comparison of the (1)H NMR and mass spectrometry spectral data of an authentic sample.

The oral administration of ergosterol to sarcoma 180-bearing mice significantly reduced tumor growth at doses of 400 and 800 mg/kg administered for 20 d without side effects, such as the decreases in body, epididymal adipose tissue, thymus, and spleen weights and leukocyte numbers induced by cancer chemotherapy drugs.

Ergosterol had no cytotoxicity against tumor cells. To clarify the antitumor activity of ergosterol, we examined the effects of ergosterol on tumor-induced angiogenesis using two in vivo models. Intraperitoneal administration of ergosterol at doses of 5, 10 and 20 mg/kg for 5 consecutive d inhibited the neovascularization induced by Lewis lung carcinoma cell-packed chambers, suggesting that either ergosterol or its metabolites may be involved in the inhibition of tumor-induced neovascularization.

Therefore, we further examined the inhibitory effects of ergosterol on Matrigel-induced neovascularization. Female C57BL/6 mice were subcutaneously inoculated with Matrigel containing acidic fibroblast growth factor and heparin with or without ergosterol. Ergosterol inhibited the Matrigel-induced neovascularization, suggesting that ergosterol directly inhibits Matrigel-induced neovascularization.

From these results, it seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors. This is the first report of ergosterol as an antiangiogenic substance.


 


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